Differential expression of thioredoxin binding protein‐2/Txnip in human placenta: Possible involvement of hypoxia in its suppression during early pregnancy

详细信息    查看全文

• 作者：Haruta Mogami ; Shigeo Yura ; Eiji Kondoh ; Hiroshi Masutani ; Junji Yodoi ; Ikuo Konishi
• 刊名：Journal of Obstetrics and Gynaecology Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：43
• 期：1
• 页码：50-56
• 全文大小：300.6KB
• ISSN：1447-0756

文摘

Thioredoxin binding protein-2 (TBP-2), which is identical to thioredoxin interacting protein (Txnip), controls cellular proliferation and differentiation. The aim of the present study was to compare TBP-2 protein and mRNA expression in human placenta during the three trimesters of pregnancy and to investigate the role of hypoxia in the change of these expressions in placental tissue. A secondary objective was to determine the gene expression of peroxisome proliferator-activated receptors (PPARs) in TBP-2 deficient placenta using TBP-2 gene disrupted mice (TBP-2^−/−).