Tigecycline Reduces Ethanol Intake in Dependent and Nondependent Male and Female C57BL/6J Mice
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- 作者：Susan E. Bergeson ; Michelle A. Nipper ; Jeremiah Jensen ; Melinda L. Helms and Deborah A. Finn
- 刊名：Alcoholism: Clinical and Experimental Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：40
- 期：12
- 页码：2491-2498
- 全文大小：421K
- ISSN：1530-0277
文摘
The chronic intermittent ethanol (CIE) paradigm is valuable for screening compounds for efficacy to reduce drinking traits related to alcohol use disorder (AUD), as it measures alcohol consumption and preference under physical dependence conditions. Air control-treated animals allow simultaneous testing of similarly treated, nondependent animals. As a consequence, we used CIE to test the hypothesis that tigecycline, a semisynthetic tetracycline similar to minocycline and doxycycline, would reduce alcohol consumption regardless of dependence status.