Genetic variants in CETP increase risk of intracerebral hemorrhage
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- 作者：Christopher D. Anderson ; Guido J. Falcone ; Chia-Ling Phuah ; Farid Radmanesh ; H. Bart Brouwers ; Thomas W. K. Battey ; Alessandro Biffi ; Gina M. Peloso ; Dajiang J. Liu ; Alison M. Ayres ; Joshua N. Goldstein ; Anand Viswanathan ; Steven M. Greenberg ; Magdy Selim ; James F. Meschia ; Devin L. Brown ; Bradford B. Worrall ; Scott L. Silliman ; David L. Tirschwell ; Matthew L. Flaherty ; Peter Kraft ; Jeremiasz M. Jagiella ; Helena Schmidt ; Bjö ; rn M. Hansen ; Jordi Jimenez-Conde ; Eva Giralt-Steinhauer ; Roberto Elosua ; Elisa Cuadrado-Godia ; Carolina Soriano ; Koen M. van Nieuwenhuizen ; Catharina J. M. Klijn ; Kristiina Rannikmae ; Neshika Samarasekera ; Rustam Al-Shahi Salman ; Catherine L. Sudlow ; Ian J. Deary ; Andrea Morotti ; Alessandro Pezzini ; Joanna Pera ; Andrzej Urbanik ; Alexander Pichler ; Christian Enzinger ; Bo Norrving ; Joan Montaner ; Israel Fernandez-Cadenas ; Pilar Delgado ; Jaume Roquer ; Arne Lindgren ; Agnieszka Slowik ; Reinhold Schmidt ; Chelsea S. Kidwell ; Steven J. Kittner ; Salina P. Waddy ; Carl D. Langefeld ; Goncalo Abecasis ; Cristen J. Willer ; Sekar Kathiresan ; Daniel Woo ; Jonathan Rosand and on behalf of the Global Lipids Genetics Consortium and International Stroke Genetics Consortium
- 刊名：Annals of Neurology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：80
- 期：5
- 页码：730-740
- 全文大小：169K
- ISSN：1531-8249
文摘
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. Here, we test the hypothesis that CETP DNA sequence variants associated with higher HDL-C also increase risk for ICH.