The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health
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- 作者：Richard D. Horniblow ; Gladys O. Latunde-Dada ; Stephen E. Harding ; Melanie Schneider ; Fahad M. Almutairi ; Manroy Sahni ; Ahsan Bhatti ; Christian Ludwig ; Ian T. Norton ; Tariq H. Iqbal and Chris Tselepis
- 刊名：Molecular Nutrition & Food Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：60
- 期：9
- 页码：2098-2108
- 全文大小：1095K
- ISSN：1613-4133
文摘
Iron is an essential nutrient. However, in animal models, excess unabsorbed dietary iron residing within the colonic lumen has been shown to exacerbate inflammatory bowel disease and intestinal cancer. Therefore, the aims of this study were to screen a panel of alginates to identify a therapeutic that can chelate this pool of iron and thus be beneficial for intestinal health.