Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs

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• 作者：Bereket Mochona ; Timothy Jackson ; DeCoria McCauley ; Elizabeth Mazzio and Kinfe K. Redda
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：53
• 期：6
• 页码：1871-1877
• 全文大小：738K
• ISSN：1943-5193

文摘

Azomethine-linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4-oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, ¹H-NMR, ¹³C-NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer cell lines (MDA-AB-231, BT-474, and Ishikawa cells) revealed that the pyrrole–benzimidazole hybrids are more potent than the pyrazolone and 1,3,4-oxadiazole hybrids in all cell lines. Compound ref="#jhet2501-eo-0027" rel="references:#jhet2501-eo-0027"> displayed promising cytotoxicity against BT-474 cell line with ICb>50b> values, 7.7 µM.