High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia

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• 作者：Miguel A. Frias ; Auré ; lien Thomas ; Marie-Claude Brulhart-Meynet ; Oskar Kö ; vamees ; John Pernow ; Mats Eriksson ; Bo Angelin ; Richard W. James and Jonas W. Brinck
• 刊名：European Journal of Clinical Investigation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：1
• 页码：38-43
• 全文大小：155K
• ISSN：1365-2362

文摘

Patients with heterozygous familial hypercholesterolaemia (FH) suffer from high plasma cholesterol and an environment of increased oxidative stress. We examined its potential effects on high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) content (HDL-S1P) and HDL-mediated protection against oxidative stress, both with and without statin treatment.