Cellular Uptake: Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling (Adv. Healthcare Mater. 24/2016)
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- 作者：Janine Broda ; Andrea Kü ; ster ; Stefan Westhues ; Dirk Fahrenkamp ; Andreas T. J. Vogg ; Julia Steitz ; Felix M. Mottaghy ; Gerhard Mü ; ller-Newen and Ulrich Simon
- 刊名：Advanced Healthcare Materials
- 出版年：2016
- 出版时间：December 21, 2016
- 年：2016
- 卷：5
- 期：24
- 页码：3088
- 全文大小：1618K
- ISSN：2192-2659
文摘
On page 3118, a new hybrid structure consisting of a cytotoxic 1.4 nm sized gold core surrounded by a fluorophore-containing ligand shell is designed to monitor cellular uptake by Ulrich Simon and co-workers. The evolution of fluorescence upon cellular uptake discloses that the loss of the ligand shell or of parts of is the essential to unfold high AuNP cytotoxicity.