On the synthesis of cyclodextrin-peptide conjugates by the Huisgen reaction

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• 作者：Ré ; my Lartia ; Christopher K. Jankowski and Sé ; bastien Arseneau
• 刊名：Journal of Peptide Science
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：22
• 期：8
• 页码：511-516
• 全文大小：819K
• ISSN：1099-1387

文摘

A,D-substituted cyclodextrin (CDX) substituted on their primary rim side are ideal scaffolds for the macromolecular assembly and formation of templated structures. Their substitution can be achieved through various reactions. However, the use of the well-known Huisgen reaction in this context is under-reported. We present here results of the synthesis of model conjugates formed between CDX and representative peptides by click chemistry. Notably, bis-conjugation of peptides onto a unique scaffold promotes α-helix formation. Copyright