文摘
A new, radical-mediated, divergent bicyclization of 1,n-enynes by α-C(sp3)–H oxidative functionalization of alkyl nitriles is described using the Sc(OTf)3 and Ag2O system. The reaction allows the selective functionalization of one or two C(sp3)−H bonds α to the nitrile group by both oxidants and the substitution effect co-controlled the divergent bicyclization reactions, and offers a step- and atom-economical access to diverse polycycles with broad substrate scope and high selectivity.