Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols

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• 作者：Francis Mariaraj Irudayanathan ; Prof. Jimin Kim ; Prof. Kwang Ho Song and Prof. Sunwoo Lee
• 刊名：Asian Journal of Organic Chemistry
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：5
• 期：9
• 页码：1148-1154
• 全文大小：476K
• ISSN：2193-5815

文摘

Propargyl alcohols have been directly synthesized by decarboxylative coupling reactions with an alkynyl carboxylic acid and an aldehyde/ketone in the absence of a transition-metal catalyst. When the decarboxylative coupling reaction was conducted with Cs₂CO₃ in DMSO, the desired propargyl alcohols were formed in good yield. In addition, the reactions with 2,2,2-trifluoroacetophenone and aryl alkynyl carboxylic acids gave trifluoromethylated propargyl alcohols.