Ligand-Free, Cu- and Fe-Catalyzed Selective Ring-Opening Arylations of Benzoxazoles with Aryl Iodides

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• 作者：Yue He ; Prof. Dr. Jincheng Mao ; Guangwei Rong ; Hong Yan and Prof. Dr. Guoqi Zhang
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：June 6, 2016
• 年：2016
• 卷：11
• 期：11
• 页码：1672-1676
• 全文大小：463K
• ISSN：1861-471X

文摘

Cu- or Fe-based catalyst systems have been reported to selectively catalyze the N,N-diarylation or N-monoarylation of benzoxazoles ring-opening with aryl iodides in the absence of additional added ligand in polyethylene glycol under an inert atmosphere. Two types of coupling products (triphenylamines and diphenylamines) have been examined and the reaction routes can be simply controlled by changing the metal salts (Cu or Fe) as catalyst. A range of substrates have been investigated for the diverse reactions, and the corresponding arylation products were achieved in good to high yields. This selective, low-cost, and environmentally friendly protocol displays great potential for replacing existing methodologies as well as extending the synthetic applications of benzoxazoles.