Copper, Silver and Sodium Salt-Mediated Quaternization by Arylation: Syntheses of N-Heterocyclic Carbene Precursors and 6-H-Phenanthridine Derivatives

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• 作者：Wenqi Shen ; Jing Li ; Caiyun Zhang ; Prof. Dr. Min Shi and Dr. Jun Zhang
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：July 5, 2016
• 年：2016
• 卷：11
• 期：13
• 页码：1883-1886
• 全文大小：419K
• ISSN：1861-471X

文摘

We have developed a Cu^II-, Ag^I-, and NaOTf-mediated intramolecular quaternization by arylation reactions to synthesize a variety of N-heterocyclic carbene (NHC) precursors with a benzene-fused backbone. The methodology also provides a convenient alternative route for the synthesis of 6-H-phenanthridine derivatives. A novel silver–NHC complex was prepared by treatment of Ag₂O with the free carbene, which was in situ prepared from the deprotonation of a representative quinazolinonium salt.