Mesoporous Bioactive Glass Nanolayer-Modified Zirconia Coatings on Ti-6Al-4V with Improved In Vitro Bioactivity

详细信息    查看全文

• 作者：Yali Zhang ; Lei Chen ; Mengchao Shi ; Dong Zhai ; Huiying Zhu ; Jiang Chang ; Chengtie Wu ; Xuebin Zheng and Jingbo Yin
• 刊名：International Journal of Applied Glass Science
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：7
• 期：2
• 页码：216-228
• 全文大小：1349K
• ISSN：2041-1294

文摘

The bioactivity of coatings on alloy implants plays critical roles in the fast osteointegration and maintenance of a long-term life span of the implants. The aim of this study is to incorporate nanopores and bioactive components into the plasma-sprayed coatings by constructing nanopores and bioactive elements on the surface of coatings and further improve their in vitro bone-forming activity. In this study, mesoporous bioactive glasses (MBG) were used for modifying the surface of ZrO₂ coatings on Ti-6Al-4V by spin-coating methods. The result shows that MBG nanolayer has been successfully coated on the surface of ZrO₂ coatings. The MBG-modified ZrO₂ coatings have improved apatite-mineralization ability and stable bonding strength. In addition, the attachment, proliferation, alkaline phosphate activity, and bone-related gene expression of rabbit bone marrow stromal cells on MBG-ZrO₂ coating were also enhanced as compared with conventional bioactive glass-modified ZrO₂ coatings and pure ZrO₂ coatings. The results indicated that MBG-modified ZrO₂ coatings on Ti alloy are promising for orthopedic application.