Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation
详细信息 查看全文
- 作者：Yuqi Zhang ; Jicheng Yu ; Jinqiang Wang ; Nicholas J. Hanne ; Zheng Cui ; Chenggen Qian ; Chao Wang ; Hongliang Xin ; Jacqueline H. Cole ; Caterina M. Gallippi ; Yong Zhu and Zhen Gu
- 刊名：Advanced Materials
- 出版年：2017
- 出版时间：January 25, 2017
- 年：2017
- 卷：29
- 期：4
- 全文大小：1754K
- ISSN：1521-4095
文摘
A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner. This microneedle-based patch can sense activated thrombin and subsequently releases heparin to prevent coagulation in the blood flow. This “smart” heparin patch can be transcutaneously inserted into skin without drug leakage and can sustainably regulate blood coagulation in response to thrombin.