Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies
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- 作者：Marta Marquié ; Marc D. Normandin ; Avery C. Meltzer ; Michael Siao Tick Chong ; Nicolas V. Andrea ; Alejandro Antó ; n-Ferná ; ndez ; William E. Klunk ; Chester A. Mathis ; Milos D. Ikonomovic ; Manik Debnath ; Elizabeth A. Bien ; Charles R. Vanderburg ; Isabel Costantino ; Sara Makaretz ; Sarah L. DeVos ; Derek H. Oakley ; Stephen N. Gomperts ; John H. Growdon ; Kimiko Domoto-Reilly ; Diane Lucente ; Bradford C. Dickerson ; Matthew P. Frosch ; Bradley T. Hyman ; Keith A. Johnson and Teresa Gó ; mez-Isla
- 刊名：Annals of Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：81
- 期：1
- 页码：117-128
- 全文大小：1160K
- ISSN：1531-8249
文摘
Recent studies have shown that positron emission tomography (PET) tracer AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of in vivo and postmortem AV-1451 binding patterns in three autopsy-confirmed non-Alzheimer tauopathy cases.