The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity

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• 作者：Ioannis Kalampokis ; Guglielmo M. Venturi ; Jonathan C. Poe ; Jeffrey A. Dvergsten ; John W. Sleasman and Thomas F. Tedder
• 刊名：Arthritis & Rheumatism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：69
• 期：1
• 页码：225-238
• 全文大小：1040K
• ISSN：1529-0131

文摘

Regulatory B cells that inhibit immune responses through interleukin-10 (IL-10) secretion (B10 cells) have been characterized in adult subjects with autoimmune disease. The aim of this study was to characterize B10 cells in individuals across the entire age range of normal human development and changes in their frequency and numbers in children with autoimmunity.