Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ^12, 14-PGJ₂

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• 作者：Dr. Kyeojin Kim ; Dr. Jong-Min Park ; Prof. Nam-Jung Kim ; Dr. Su-Jung Kim ; Hyunyoung Moon ; Dr. Hongchan An ; Prof. Jeeyeon Lee ; Prof. Hyun-Ju Park ; Prof. Young-Joon Surh and Prof. Young-Ger Suh
• 刊名：ChemBioChem
• 出版年：2016
• 出版时间：October 17, 2016
• 年：2016
• 卷：17
• 期：20
• 页码：1900-1904
• 全文大小：1125K
• ISSN：1439-7633

文摘

Mechanism-based chemical transformation of 15-deoxy-Δ^12, 14-PGJ₂ (15d-PGJ₂) resulted in a series of new NF-E2-related factor-2 (Nrf2) activators and detailed elucidation of the function of each electrophilic binding site. In addition, HO-1 expression resulting from Nrf2 activation through enhanced dissociation of the Keap1–Nrf2 complex by the new activators was proved.