Quantitative assessment of organ distribution of dietary protein-bound ¹³C-labeled N^ɛ-carboxymethyllysine after a chronic oral exposure in mice

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• 作者：Fré ; dé ; ric J. Tessier ; Cé ; line Niquet-Lé ; ridon ; Philippe Jacolot ; Cé ; line Jouquand ; Michaë ; l Genin ; Ann-Marie Schmidt ; Nicolas Grossin and Eric Boulanger
• 刊名：Molecular Nutrition & Food Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：60
• 期：11
• 页码：2446-2456
• 全文大小：541K
• ISSN：1613-4133

文摘

N^ɛ-Carboxymethyl-lysine (CML) is a prominent advanced glycation end-product which is not only found in vivo but also in food. It is known that a percentage of the dietary CML (dCML) is absorbed into the circulation and only partly excreted in the urine. Several studies have tried to measure how much dCML remains in tissues. However obstacles to interpreting the data have been found.