pH-Dependent Cancer-Directed Photodynamic Therapy by a Water-Soluble Graphitic-Phase Carbon Nitride-Porphyrin Nanoprobe

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• 作者：Chi-Fai Chan ; Yan Zhou ; Hongyu Guo ; Dr. Junying Zhang ; Lijun Jiang ; Prof. Wei Chen ; Dr. Kwok-Keung Shiu ; Prof. Wai-Kwok Wong and Dr. Ka-Leung Wong
• 刊名：ChemPlusChem
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：81
• 期：6
• 页码：535-540
• 全文大小：1304K
• ISSN：2192-6506

文摘

Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water-soluble graphitic-phase carbon nitride-based material (g-C₃N₄) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μm mg⁻¹ mL⁻¹) is shown to be a new concept of photodynamic therapeutic agent (g-C₃N₄–P2). The pH-sensitive emission of g-C₃N₄ is the driving force for the generation of ¹O₂ from g-C₃N₄–P2. The amount of ¹O₂/light generated from a photosensitizer porphyrin can be controlled by the pH-sensitive emission of g-C₃N₄ at acidic pH (pH 4–6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer-selective PDT agent.