Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences

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• 作者：Alastair O&#39 ; Brien ; Louise China ; Karen A. Massey ; Anna Nicolaou ; Alison Winstanley ; Justine Newson ; Adrian Hobbs ; Tatsiana Audzevich and Derek W. Gilroy
• 刊名：Liver International
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：36
• 期：6
• 页码：837-846
• 全文大小：813K
• ISSN：1478-3231

文摘

Patients with decompensated cirrhosis are susceptible to infection. Innate immune dysfunction and development of organ failure are considered to underlie this. A rodent model of liver disease sharing these phenotypic features would assist in vivo study of underlying mechanisms and testing of therapeutics. We evaluated three models to identify which demonstrated the greatest clinical and immunological phenotypic similarity to patients with acutely decompensated (AD) cirrhosis.