Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations
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- 作者：Ji Yih Chen ; Yee Ling Wu ; Mo Yin Mok ; Yeong-Jian Jan Wu ; Katherine E. Lintner ; Chin-Man Wang ; Erwin K. Chung ; Yan Yang ; Bi Zhou ; Huanyu Wang ; Denise J. H. C. Yu ; Alaaedin Alhomosh ; Karla Jones ; Charles H. Spencer ; Haikady N. Nagaraja ; Yu Lung Lau ; Chak-Sing Lau and C. Yung Yu
- 刊名：Arthritis & Rheumatism
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：68
- 期：6
- 页码：1442-1453
- 全文大小：277K
- ISSN：1529-0131
文摘
Human complement C4 is complex, with multiple layers of diversity. The aims of this study were to elucidate the copy number variations (CNVs) of C4A and C4B in relation to disease risk in systemic lupus erythematosus (SLE), and to compare the basis of race-specific C4A deficiency between East Asians and individuals of European descent.