Synthesis, characterization, photoluminescence and electrochemical properties of Pt(II) and Ag(I) complexes of tetradentate aminomethylphosphine ligands and antiproliferative activities on HT-29 human colon cancer

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• 作者：Serhan Uruş ; Mahmut İncesu ; Seda Kö ; şker ; Akif Hakan Kurt and Gö ; khan Ceyhan
• 刊名：Applied Organometallic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 全文大小：2342K
• ISSN：1099-0739

文摘

Novel N¹,N¹,N⁴,N⁴-tetrakis((diphenylphosphino)methyl)benzene-1,4-diamine (), N¹,N¹,N⁵,N⁵-tetrakis((diphenylphosphino)methyl)naphthalene-1,5-diamine () and 4,4′-methylenebis(N,N-bis((diphenylphosphino)methyl)aniline) () ligands and their Pt(II) and Ag(I) complexes have been synthesized under nitrogen atmosphere using the Schlenk technique. The ligands and the complexes were characterized using ¹H NMR, ³¹P NMR and Fourier transform infrared spectroscopies, thermogravimetric/differential thermal analysis, elemental analysis (C, H, N), inductively coupled plasma optical emission spectrometry (metal content), cyclic voltammetry and photoluminescence. All the complexes were investigated as anticancer agents on HT-29 human colon cancer cell line. HT-29 cells were treated with various concentrations (10, 25, 50, 100, 250 μM) of Pt(II) and Ag(I) tetrakisditertiaryaminomethylphosphine complexes. Cisplatin was tested at the same concentrations in order to compare the antiproliferative activities of the synthesized Pt(II) and Ag(I) complexes. Pt(II) complexes of and and Ag(I) complexes of , and showed a similar inhibition effect of cancer cell proliferation when compared to cisplatin up to 50 μM; at 100 μM and higher concentrations, L1–Pt(II) and L3–Ag(I) complexes showed a much greater effect than cisplatin. Copyright