Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
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- 作者：Dr. Jonas G. Croissant ; Yevhen Fatieiev ; Dr. Khachatur Julfakyan ; Jie Lu ; Dr. Abdul-Hamid Emwas ; Dr. Dalaver H. Anjum ; Haneen Omar ; Prof. Fuyuhiko Tamanoi ; Prof. Jeffrey I. Zink and Prof. Niveen M. Khashab
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：October 10, 2016
- 年：2016
- 卷：22
- 期：42
- 页码：14806-14811
- 全文大小：6705K
- ISSN：1521-3765
文摘
We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.