Frontispiece: Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
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- 作者：Dr. Jonas G. Croissant ; Yevhen Fatieiev ; Dr. Khachatur Julfakyan ; Jie Lu ; Dr. Abdul-Hamid Emwas ; Dr. Dalaver H. Anjum ; Haneen Omar ; Prof. Fuyuhiko Tamanoi ; Prof. Jeffrey I. Zink and Prof. Niveen M. Khashab
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：October 10, 2016
- 年：2016
- 卷：22
- 期：42
- 全文大小：2437K
- ISSN：1521-3765
文摘
Nanotechnology Biodegradable hybrid materials that combine high porosity and drug payload without drug leakage are in high demand. In their Communication on page 14806 ff., N. M. Khashab and et al. report the first completely biodegradable mesoporous hybrid nanovectors in the presence of proteases. Oxamide-phenylene-based mesoporous organosilica nanoparticles were synthesized with oxamide functions to enable the biodegradability in the presence of trypsin. Exceptionally high payloads of drugs (up to 84 wt%) and a unique zero premature leakage without the pore capping were observed.