IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

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• 作者：Lei Chen ; Lika'a Fasih Y. Al-Kzayer ; Tingting Liu ; Norimoto Kobayashi ; Yozo Nakazawa and Kenichi Koike
• 刊名：Pediatric Blood & Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：64
• 期：2
• 页码：311-314
• 全文大小：511K
• ISSN：1545-5017

文摘

IRF4/MUM1-positive lymphoma is a new subgroup of germinal center-derived B-cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7-year-old Chinese male with B-cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1-positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1-positive lymphoma in WR with co-expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity.