Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle
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- 作者：Tim Koopmans ; Stijn Crutzen ; Mark H Menzen ; Andrew J Halayko ; Tillie-Louise Hackett ; Darryl A Knight and Reinoud Gosens
- 刊名：British Journal of Pharmacology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：173
- 期：23
- 页码：3327-3341
- 全文大小：2265K
- ISSN：1476-5381
文摘
Asthma is a heterogeneous chronic inflammatory disease, characterized by the development of structural changes (airway remodelling). β-catenin, a transcriptional co-activator, is fundamentally involved in airway smooth muscle growth and may be a potential target in the treatment of airway smooth muscle remodelling.