Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue
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- 作者：Kristen T. Crowell ; Jennifer L. Steiner ; Catherine S. Coleman and Charles H. Lang
- 刊名：Alcoholism: Clinical and Experimental Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：40
- 期：9
- 页码：1832-1845
- 全文大小：691K
- ISSN：1530-0277
文摘
Chronic alcohol consumption leads to a loss of white adipose tissue (WAT) but the underlying mechanisms for this lipodystrophy are not fully elucidated. This study tested the hypothesis that the reduction in WAT mass in chronic alcohol-fed mice is associated with a decreased protein synthesis specifically related to impaired function of mammalian target of rapamycin (mTOR).