ChemInform Abstract: Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams.
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- 作者：Stephen W. Wright ; Chulho Choi ; Seungwon Chung ; Brian P. Boscoe ; Susan E. Drozda ; James J. Mousseau and John D. Trzupek
- 关键词：oxazole derivatives ; C-C bond formation ; spirocyclic compounds (heterocyclic compounds) ; reactions of organo-metal compounds
- 刊名：ChemInform
- 出版年：2016
- 出版时间：March, 2016
- 年：2016
- 卷：47
- 期：12
- 全文大小：34K
- ISSN：1522-2667
文摘
Pyroglutaminol-derived bicyclic ,β-unsaturated lactams in which the aminal moiety originates from ketones afford products from syn-conjugate addition whereas the corresponding lactams with an aldehyde-derived aminal moiety deliver anti-conjugate products.