Photocatalytic Degradation of Cell Membrane Coatings for Controlled Drug Release

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• 作者：Lang Rao ; Qian-Fang Meng ; Qinqin Huang ; Pei Liu ; Lin-Lin Bu ; Kiran Kumar Kondamareddy ; Shi-Shang Guo ; Wei Liu and Xing-Zhong Zhao
• 刊名：Advanced Healthcare Materials
• 出版年：2016
• 出版时间：June 22, 2016
• 年：2016
• 卷：5
• 期：12
• 页码：1420-1427
• 全文大小：1609K
• ISSN：2192-2659

文摘

Biomimetic cell-membrane–camouflaged particles with desirable features have been widely used for various biomedical applications. However, there are few reports on employing these particles for cancer drug delivery due to the failure of the membrane coatings to be efficiently degraded in the tumor microenvironment which hampers the drug release. In this work, core–shell SiO₂@TiO₂ nanoparticles with enhanced photocatalytic activity are used for controlled degradation of surface erythrocyte membrane coatings. The antitumor drug docetaxel is encapsulated into nanocarriers to demonstrate the controlled drug release under ultraviolet irradiation, and the drug-loaded nanoparticles are further used for enhanced cancer cell therapy. Here, a simple but practical method for degradation of cell membrane coatings is presented, and a good feasibility of using cell membrane–coated nanocarriers for controlled drug delivery is demonstrated.