Design and Synthesis of Novel 6-(5-Methyl-1H-1,2,3-triazol-4-yl)-5-[(2-(thiazol-2-yl)hydrazono)methyl]imidazo[2,1-b]thiazoles as Antimicrobial Agents

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• 作者：Bakr F. Abdel-Wahab ; Rizk E. Khidre and Ghada E. A. Awad
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：489-494
• 全文大小：425K
• ISSN：1943-5193

文摘

Novel 6-(1,2,3-triazol-4-yl)-5-[(2-(thiazol-2-yl)hydrazono)methyl]imidazo[2,1-b]thiazoles f="#jhet2610-eo-0015" rel="references:#jhet2610-eo-0015">, f="#jhet2610-eo-0022" rel="references:#jhet2610-eo-0022 #jhet2610-eo-0023 #jhet2610-eo-0024 #jhet2610-eo-0025">, and f="#jhet2610-eo-0027" rel="references:#jhet2610-eo-0027"> were prepared by reaction of thiosemicarbazone f="#jhet2610-eo-0012" rel="references:#jhet2610-eo-0012 #jhet2610-eo-0013"> with either hydrazonoyl chloride f="#jhet2610-eo-0014" rel="references:#jhet2610-eo-0014">, phenacylbromides f="#jhet2610-eo-0016" rel="references:#jhet2610-eo-0016"> or line-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2610-eo-0004">line-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2610-eo-0026">2-bromo-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)ethanone f="#jhet2610-eo-0026" rel="references:#jhet2610-eo-0026"> respectively. The new products were tested for their antimicrobial activities using 96-well micro-plate assay, and compound f="#jhet2610-eo-0015" rel="references:#jhet2610-eo-0015"> showed excellent antibacterial activities compared with Vancomycine (reference drugs), while compounds f="#jhet2610-eo-0013" rel="references:#jhet2610-eo-0013"> and f="#jhet2610-eo-0024" rel="references:#jhet2610-eo-0024"> exhibited good results against yeast. The minimum inhibitory concentration (MIC) was determined, and compound f="#jhet2610-eo-0015" rel="references:#jhet2610-eo-0015"> showed the lowest MIC against Gram positive bacteria while compound f="#jhet2610-eo-0013" rel="references:#jhet2610-eo-0013"> showed the lowest MIC against yeast.