Evaluation of assay interference and interpretation of CXCR4 receptor occupancy results in a preclinical study with MEDI3185, a fully human antibody to CXCR4
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- 作者：Martin Schwickart ; Carlos Chavez ; Simon Henderson ; Inna Vainshtein ; Nathan Standifer ; Christopher DelNagro ; Freshta Mehrzai ; Amy Schneider ; Lorin Roskos and Meina Liang
- 关键词：receptor occupancy ; pharmacodynamic biomarker ; biopharmaceutical ; flow cytometry ; antidrug antibodies ; antitherapeutic antibodies ; MEDI3185
- 刊名：Cytometry Part B: Clinical Cytometry
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：90
- 期：2
- 页码：209-219
- 全文大小：746K
- ISSN：1552-4957
文摘
Receptor occupancy (RO) assays provide a means to measure the direct interaction of therapeutics with their cell surface targets. Free receptor assays quantify cell-surface receptors not bound by a therapeutic while total receptor assays quantify the amount of target on the cell surface.