Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity

详细信息    查看全文

• 作者：Elisha M. Wachman ; Marie J. Hayes ; Richard Sherva ; Mark S. Brown ; Hira Shrestha ; Beth A. Logan ; Nicole A. Heller ; David A. Nielsen and Lindsay A. Farrer
• 刊名：The American Journal on Addictions
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：1
• 页码：42-49
• 全文大小：91K
• ISSN：1521-0391

文摘

There is significant variability in severity of neonatal abstinence syndrome (NAS) due to in utero opioid exposure. Our previous study identified single nucleotide polymorphisms (SNPs) in the prepronociceptin (PNOC) and catechol-O-methyltransferase (COMT) genes that were associated with differences in NAS outcomes. This study looks at the same SNPs in PNOC and COMT in an independent cohort in an attempt to replicate previous findings.