Inside Cover: Metal-Organic-Framework-Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small-Molecule-Polymer Conjugates (Chem. Asian J. 12/2016)
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- 作者：Shuo Liu ; Jianbin Chen ; Xiaojia Bao ; Tao Li ; Yunyang Ling ; Chunxiang Li ; Prof. Dr. Chuanliu Wu and Prof. Dr. Yibing Zhao
- 刊名：Chemistry – An Asian Journal
- 出版年：2016
- 出版时间：June 21, 2016
- 年：2016
- 卷：11
- 期：12
- 页码：1748
- 全文大小：776K
- ISSN：1861-471X
文摘
Nanoscale metal–organic frameworks are exploited as templates for the fabrication of layer-by-layer polyelectrolyte nanocapsules. As small-molecule drugs or imaging agents cannot be efficiently encapsulated by polyelectrolyte nanocapsules, two polymers (i.e., comb-shaped and hyperbranched polyethylene glycol) were used for the conjugation of model drugs and imaging agents, which were then encapsulated inside the nanocapsules. Additionally, it was systematically examined how the encapsulation efficiency and release kinetics of the conjugates can be controlled by varying the composition and architectures of the polymers. More information can be found in the Full Paper by Chuanliu Wu, Yibing Zhao, and co-workers on page 1811 in Issue 12, 2016 (DOI: 10.1002/asia.201600250).