Alcohol Exposure Causes Overexpression of Heart Development-Related Genes by Affecting the Histone H3 Acetylation via BMP Signaling Pathway in Cardiomyoblast Cells
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- 作者：Jin Shi ; Weian Zhao ; Bo Pan ; Min Zheng ; Lina Si ; Jing Zhu ; Lingjuan Liu and Jie Tian
- 刊名：Alcoholism: Clinical and Experimental Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：41
- 期：1
- 页码：87-95
- 全文大小：565K
- ISSN：1530-0277
文摘
Abusive alcohol utilization of pregnant woman may cause congenital heart disease (CHD) of fetus, where alcohol ignites histone H3 hyperacetylation leading to abnormal development of heart morphogenesis and associated genes. Knowledge about the regularized upstream genes is little, but bone morphogenetic protein (BMP) signaling may actively and prominently take part in alteration in acetylation of histone H3. The supreme objective of this study was to unearth the involvement of BMP signaling pathway in alcohol-driven hyperacetylation of histone H3 in cardiomyoblast cells.