Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population
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- 作者：Na Yang ; Linlin Wang ; Richard H. Finnell ; Zhiwen Li ; Lei Jin ; Le Zhang ; Robert M. Cabrera ; Rongwei Ye and Aiguo Ren
- 刊名：Birth Defects Research Part A: Clinical and Molecular Teratology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：106
- 期：8
- 页码：685-695
- 全文大小：177K
- ISSN：1542-0760
文摘
After years of periconceptional folic acid supplementation, the prevalence of neural tube defects (NTDs) remains stable following the remarkable reduction observed immediately after the fortification practice. There is accumulating evidence that folate receptor (FR) autoimmunity may play a role in the etiology of folate-sensitive NTDs.