Positive feedback regulation between microRNA-132 and CREB in spinal cord contributes to bone cancer pain in mice

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• 作者：B. Hou ; X. Cui ; Y. Liu ; W. Zhang ; M. Liu ; Y.E. Sun ; Z. Ma and X. Gu
• 刊名：European Journal of Pain
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：20
• 期：8
• 页码：1299-1308
• 全文大小：479K
• ISSN：1532-2149

文摘

cAMP response element-binding protein (CREB)-dependent gene expression plays an important role in central sensitization. CREB-regulated transcription coactivator 1 (CRTC1) dramatically increase CREB-mediated transcriptional activity. microRNA-132 (miR-132), which is highly CREB-responsive, functions downstream from CREB/CRTC1 to mediate activity-dependent synaptic plasticity and in turn loops back to amplify CREB/CRTC1 signalling. This study aimed to investigate the positive feedback regulation between miR-132 and CREB in spinal cord in the maintenance of bone cancer pain.