Reference ranges of lymphocyte subsets balanced for age and gender from a population of healthy adults in Chongqing District of China

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• 作者：Kejun Zhang ; Feng Wang ; Mingxu Zhang ; Xinglu Cao ; Shaojun Yang ; Shuangrong Jia ; Lixin Wang ; Jie Luo ; Shaoli Deng and Ming Chen
• 刊名：Cytometry Part B: Clinical Cytometry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：90
• 期：6
• 页码：538-542
• 全文大小：75K
• ISSN：1552-4957

文摘

The enumeration of lymphocyte subsets plays an essential role in the monitoring of immunological disorders. Immunophenotyping values have been found to be influenced by race, age, gender, and environmental conditions. Therefore, it is important to establish reference ranges for healthy adults from the local population for clinical decision-making. The current study aimed to establish a normal reference range for peripheral blood lymphocyte subsets in healthy adults from the Chongqing District of China by using single-platform flow cytometry. Age- and gender-specific reference ranges were established in 268 healthy adult males and females between 21 and 60 years of age. The CD8+ cell counts decreased with age, CD4+ cell percentages and counts increased with age, and total T cell percentages were higher in the female population. Our results are similar to those reported from other parts of China but different from some results reported from other countries; this further stresses the need to establish local reference ranges by region. Our results will help in the management of patients with human immunodeficiency virus and other immunological disorders in Chongqing District.