Cypate-Conjugated Porous Upconversion Nanocomposites for Programmed Delivery of Heat Shock Protein 70 Small Interfering RNA for Gene Silencing and Photothermal Ablation

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• 作者：Lu Wang ; Chang Gao ; Keyin Liu ; Yuxin Liu ; Liyi Ma ; Lidong Liu ; Xiaoxia Du and Jing Zhou
• 刊名：Advanced Functional Materials
• 出版年：2016
• 出版时间：May 24, 2016
• 年：2016
• 卷：26
• 期：20
• 页码：3480-3489
• 全文大小：2930K
• ISSN：1616-3028

文摘

Synergistic therapy is an accepted method of enhancing the efficacy of cancer therapies. In this study, cypate-conjugated porous NaLuF₄ doped with Yb³⁺, Er³⁺, and Gd³⁺ is synthesized and its potential for upconversion luminescence/magnetic resonance dual-modality molecular imaging for guiding oncotherapy is tested. Loading cypate-conjugated upconversion nanoparticles (UCNP-cy) with small interfering RNA gene against heat shock protein 70 (UCNP-cy-siRNA) enhances the cell damage. UCNP-cy-siRNA exhibits remarkable antitumor efficacy in vivo as a result of the synergistic effects of gene silencing and photothermal therapy, with low drug dose and minimal side effects. This result thus provides an explicit strategy for developing next-generation multifunctional nanoplatforms for multimodal imaging-guided synergistic oncotherapy.