Multifunctional Carbon-Silica Nanocapsules with Gold Core for Synergistic Photothermal and Chemo-Cancer Therapy under the Guidance of Bimodal Imaging

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• 作者：Linlin Li ; Chuanfang Chen ; Huiyu Liu ; Changhui Fu ; Longfei Tan ; Shunhao Wang ; Shiyan Fu ; Xi Liu ; Xianwei Meng and Hong Liu
• 刊名：Advanced Functional Materials
• 出版年：2016
• 出版时间：June 27, 2016
• 年：2016
• 卷：26
• 期：24
• 页码：4252-4261
• 全文大小：3689K
• ISSN：1616-3028

文摘

Carbon-based nanomaterials have been developed for photothermal cancer therapy, but it is still a great challenge to fabricate their multifunctional counterparts with facile methods, good biocompatibility and dispersity, and high efficiency for cancer theranostics. In this work, an alternative multifunctional nanoplatform is developed based on carbon–silica nanocapsules with gold nanoparticle in the cavity (Au@CSN) for cancer theranostics. The encapsulated chemodrug doxorubicin can be released from the Au@CSN with mesoporous and hollow structure in a near-infrared light and pH stimuli-responsive manner, facilitating spatiotemporal therapy to decrease off-target toxicity. The nanocapsules with efficient photothermal conversion and excellent biocompatibility achieve a synergistic effect of photothermal and chemotherapy. Furthermore, the nanocapsules can act as a multimodal imaging agent of computed tomography and photoacoustic tomography imaging for guiding the therapy. This new design platform can provide a promising strategy for precise cancer theranostics.