Targeting irradiation-induced mitogen-activated protein kinase activation in vitro and in an ex vivo model for human head and neck cancer
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- 作者：Annette Affolter ; Marie-France Muller ; Katharina Sommer ; Albrecht Stenzinger ; Karim Zaoui ; Katja Lorenz ; Thomas Wolf ; Sarika Sharma ; Janina Wolf ; Sven Perner ; Klaus-Josef Weber ; Kolja Freier ; Peter K. Plinkert ; Jochen Hess and Wilko Weichert
- 关键词：ex vivo model ; radioresistance ; head and neck cancer ; mitogen-activated protein (MAP) kinase signaling pathway ; p53 mutations ; mitogen-activated protein kinase (MEK) inhibitor
- 刊名：Head & Neck
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：38
- 期：S1
- 页码：E2049-E2061
- 全文大小：4738K
- ISSN：1097-0347
文摘
Despite new radiotherapeutic strategies, radioresistance in head and neck squamous cell carcinoma (HNSCC) remains a major problem. Preclinical model systems are needed to identify resistance mechanisms in this heterogeneous entity.