Soluble B-cell activation marker of sCD27 and sCD30 and future risk of B-cell lymphomas: A nested case-control study and meta-analyses

详细信息    查看全文

• 作者：Fatemeh Saberi Hosnijeh ; Lutzen Portengen ; Florentin Spth ; Ingvar A. Bergdahl ; Beatrice Melin ; Amalia Mattiello ; Giovanna Masala ; Carlotta Sacerdote ; Alessio Naccarati ; Vittorio Krogh ; Rosario Tumino ; Marc Chadeau-Hyam ; Paolo Vineis and Roel Vermeulen
• 关键词：lymphoma ; sCD30 ; sCD27 ; meta-analyses ; prospective study
• 刊名：International Journal of Cancer
• 出版年：2016
• 出版时间：May 15 2016
• 年：2016
• 卷：138
• 期：10
• 页码：2357-2367
• 全文大小：443K
• ISSN：1097-0215

文摘

Prediagnostic serum/plasma concentrations of B-cell activation markers have been associated with future risk of B-cell lymphomas (BCL) in HIV-infected patients and in the general population. Current evidence for the general population is however limited and relies on relatively small numbers of observations, especially for specific histologies. We carried out a nested case-control study, including 218 BCL and 218 matched controls, within two prospective cohorts, to investigate the association between plasma levels of soluble (s)CD27 and sCD30 and future risk of BCL, and main histologic subtypes separately. To expand the evidence further, we performed meta-analyses of the published data on these associations from prospective studies among the general population. Our study revealed a significant relationship between sCD30 concentration and BCL risk (OR = 0.86, 1.53, 1.76, for the 2nd–4th quartiles respectively, p trend = 0.01). Similar increased risks were observed for diffuse large B-cell lymphoma and follicular lymphoma. Analyses of sCD27 blood concentrations did not show significant associations with BCL, (OR = 0.90, 1.26, 1.65 for the 2nd–4th quartiles, respectively, p trend = 0.17), but significant associations were observed for chronic lymphocytic leukaemia and for the group of “other BCL” subtypes. Our findings involving sCD30 were confirmed within our meta-analyses of five prospective cohorts, while results were more heterogeneous for sCD27 with the exception of CLL which was found consistently in all studies. Data to date suggest that chronic B-cell stimulation might be an important mechanism involved in B-cell lymphomagenesis both in HIV-infected and in the general population.