Front Cover Picture: Cobalt-Catalyzed C−H Functionalizations by Imidate Assistance with Aryl and Alkyl Chlorides (Adv. Synth. Catal. 15/2016)

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• 作者：Ruhuai Mei and Lutz Ackermann
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：July 28, 2016
• 年：2016
• 卷：358
• 期：15
• 页码：2361
• 全文大小：571K
• ISSN：1615-4169

文摘

The front cover image, provided by Torben Rogge, Ruhuai Mei and Lutz Ackermann, illustrates the synthetic utility of cobalt-catalyzed C–H arylations by oxazoline assistance at ambient temperature. The catalytic system derived from inexpensive Co(acac)₂ and an N-heterocyclic carbene enabled C–H arylations with ample scope, and proved applicable to difficult C–H alkylations with unactivated primary and secondary alkyl chlorides. The power of the C–H arylation strategy was reflected by C–H activation at 23 °C, and late-stage diversification to access bioactive biaryls. Details can be found in the full paper on pages 2443–2448 (R. Mei, L. Ackermann, Adv. Synth. Catal. 2016, 358, 2443–2448; DOI: href="http://dx.doi.org/10.1002/adsc.201600384" rel="references:http://dx.doi.org/10.1002/adsc.201600384">10.1002/adsc.201600384).