Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of m>CDKN2A m> deletions in the m>FGFR3 m> pathway
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- 作者：Michelle R Downes ; Berber Weening ; Bas W G van Rhijn ; Cherry L Have ; Kilian M Treurniet and Theodorus H van der Kwast
- 刊名：Histopathology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：70
- 期：2
- 页码：281-289
- 全文大小：556K
- ISSN：1365-2559
文摘
The dual pathway model of urothelial carcinogenesis does not fully explain grade and stage progression in patients with initial low-grade, non-muscle invasive urothelial carcinomas. Fibroblast growth factor receptor 3 (m>FGFR3 m>) mutations are a hallmark of the low-grade pathway, with subsequent progression to muscle invasion occurring when m>FGFR3 m> mutant tumours exhibit a homozygous m>CDKN2A m> deletion. We hypothesized that grade heterogeneity represents the morphological manifestation of molecular changes associated with disease progression.