Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC)₄H₂] through a Concerted Nucleophilic Ru−H Attack Pathway

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• 作者：Mateusz K. Cybulski ; Dr. David McKay ; Prof. Stuart A. Macgregor ; Dr. Mary F. Mahon and Prof. Michael K. Whittlesey
• 刊名：Angewandte Chemie
• 出版年：2017
• 出版时间：February 1, 2017
• 年：2017
• 卷：129
• 期：6
• 页码：1537-1541
• 全文大小：901K
• ISSN：1521-3757

文摘

The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe₄)₄H₂] catalyst, 3, is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism. The calculations fully account for the observed selectivities which corroborate earlier predictions regarding the selectivity of HDF.