Manganese-Catalyzed Multicomponent Synthesis of Pyrimidines from Alcohols and Amidines
详细信息 查看全文
- 作者：Nicklas Deibl and Prof. Dr. Rhett Kempe
- 刊名：Angewandte Chemie International Edition
- 出版年：2017
- 出版时间：February 1, 2017
- 年：2017
- 卷：56
- 期：6
- 页码：1663-1666
- 全文大小：861K
- ISSN：1521-3773
文摘
The development of catalytic reactions for synthesizing different compounds from alcohols to save fossil carbon feedstock and reduce CO2 emissions is of high importance. Replacing rare noble metals with abundantly available 3d metals is equally important. We report a manganese-complex-catalyzed multicomponent synthesis of pyrimidines from amidines and up to three alcohols. Our reaction proceeds through condensation and dehydrogenation steps, permitting selective C−C and C−N bond formations. β-Alkylation reactions are used to multiply alkylate secondary alcohols with two different primary alcohols to synthesize fully substituted pyrimidines in a one-pot process. Our PN5P-Mn-pincer complexes efficiently catalyze this multicomponent process. A comparison of our manganese catalysts with related cobalt catalysts indicates that manganese shows a reactivity similar to that of iridium but not cobalt. This analogy could be used to develop further (de)hydrogenation reactions with manganese complexes.