Immunomodulatory/inflammatory effects of geopropolis produced by Melipona fasciculata Smith in combination with doxorubicin on THP-1 cells

详细信息    查看全文

• 作者：Lucas Pires Garcia Oliveira ; Fernanda Lopes Conte ; Eliza de Oliveira Cardoso ; Bruno Jos&eacute ; Conti ; Karina Basso Santiago ; Marjorie de Assis Golim ; Maria Teresa Cruz and Jos&eacute ; Maurí ; cio Sforcin
• 刊名：Journal of Pharmacy and Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：68
• 期：12
• 页码：1551-1558
• 全文大小：573K
• ISSN：2042-7158

文摘

Geopropolis (GEO) in combination with doxorubicin (DOX) reduced HEp-2 cells viability compared to GEO and DOX alone. A possible effect of this combination on the innate immunity could take place, and its effects were analysed on THP-1 cell – a human leukaemia monocytic cell line used as a model to study monocyte activity and macrophage activity, assessing cell viability, expression of cell markers and cytokine production.