Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle
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- 作者：Tanes I. Lima ; Hygor N. Araujo ; Eveline S. Menezes ; Carlos H. Sponton ; Michel B. Araú ; jo ; Lucas H.M. Bomfim ; André ; L. Queiroz ; Madla A. Passos ; Thais Amaral e Sousa ; Sandro M. Hirabara ; Amanda R. Martins ; Helena C.L.B. Sampaio ; Alice Rodrigues ; Rui Curi ; Everardo M. Carneiro ; Antô ; nio C. Boschero and Leonardo R. Silveira
- 刊名：Journal of Cellular Physiology
- 出版年：2017
- 出版时间：May 2017
- 年：2017
- 卷：232
- 期：5
- 页码：958-966
- 全文大小：341K
- ISSN：1097-4652
文摘
Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic diseases such as obesity and type 2 diabetes. MicroRNAs are non-coding RNAs that have emerged as key regulators of cell metabolism. The microRNAs act as central regulators of metabolic gene networks by leading to the degradation of their target messenger RNA or repression of protein translation. In addition, vesicular and non-vesicular circulating miRNAs exhibit a potential role as mediators of the cross-talk between the skeletal muscle and other tissues/organs. In this review, we will focus on the emerging knowledge of miRNAs controlling mitochondrial function and insulin signaling in skeletal muscle cells. J. Cell. Physiol. 232: 958–966, 2017.