Comparative assessment of clinical response in patients with rheumatoid arthritis between PF-05280586, a proposed rituximab biosimilar, and rituximab
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- 作者：Jason H. Williams ; Matthew M. Hutmacher ; Matthew L. Zierhut ; Jean-Claude Becker ; Barry Gumbiner ; George Spencer-Green ; Lisa A. Melia ; Kai-Hsin Liao ; Matthew Suster ; Donghua Yin ; Ruifeng Li and Xu Meng
- 刊名：British Journal of Clinical Pharmacology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：82
- 期：6
- 页码：1568-1579
- 全文大小：1476K
- ISSN：1365-2125
文摘
To evaluate potential differences between PF-05280586 and rituximab sourced from the European Union (rituximab-EU) and USA (rituximab-US) in clinical response (Disease Activity Score in 28 Joints [DAS28] and American College of Rheumatology [ACR] criteria), as part of the overall biosimilarity assessment of PF-05280586.