Bioinspired Microenvironments: Material-Driven Fibronectin Assembly Promotes Maintenance of Mesenchymal Stem Cell Phenotypes (Adv. Funct. Mater. 36/2016)
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- 作者：Patricia Rico ; Hayk Mnatsakanyan ; Matthew J. Dalby and Manuel Salmeró ; n-Sá ; nchez
- 刊名：Advanced Functional Materials
- 出版年：2016
- 出版时间：September 26, 2016
- 年：2016
- 卷：26
- 期：36
- 页码：6671
- 全文大小：2140K
- ISSN：1616-3028
文摘
P. Rico, M. Salmerón-Sánchez, and co-workers present an engineered material-driven fibronectin (FN) interface on page 6563. Poly(ethyl acrylate) induces spontaneous organization of FN into nanonetworks mimicking natural FN observed in biological stem cell niches. By promoting maintenance of stemness under basal conditions (undifferentiated stem cells shown in the picture), and by enhancing cell differentiation under defined media this material provides wide versatility for stem cell research and biomedical applications.