Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma

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• 作者：Robert C. Rennert ; Achal S. Achrol ; Michael Januszyk ; Suzana A. Kahn ; Tiffany T. Liu ; Yi Liu ; Debashis Sahoo ; Melanie Rodrigues ; Zeshaan N. Maan ; Victor W. Wong ; Samuel H. Cheshier ; Steven D. Chang ; Gary K. Steinberg ; Griffith R. Harsh and Geoffrey C. Gurtner
• 刊名：STEM CELLS
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：34
• 期：6
• 页码：1702-1707
• 全文大小：742K
• ISSN：1549-4918

文摘

Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;34:1702–1707